After going to Europe to have a sex change operation, Myron Breckinridge is transformed into Myra, who claims to be Myron's widow.

The career of a model ends when she is disfigured in an accident. Suspecting the accident was the work of her ex-boyfriend and his new girlfriend, she takes revenge by slipping him a drug to grow breasts.

Amanda Hardy only wants to fit in at her new school, but she is keeping a big secret, so when she falls for Grant, guarded Amanda finds herself yearning to share with him everything about herself, including her previous life as Andrew.

A novel set in Copenhagen, Paris, and Dresden in the 1920s, introduces a man who discovers he is a woman, and the woman who will do anything for him, in a tale of love and marriage in the midst of fundamental crisis.