Animosity between the genetically engineered Elites and their human subjects is fierce, and many rebels fight back against Elite rule. Hays Baker is a high-ranking agent in the Elite forces and at the forefront of keeping the humans under control. However, Hays is unknowingly hiding a secret that will make him the greatest threat to the Elite regime, and their number one target.

Heartbroken after her best friend and soul mate, Fang, leaves her flock, Maximum Ride begins to believe the evil scientists trying to convince her she needs to save the world, and that Dylan, the newest member of her flock, is her perfect mate.

Follows the adventures of Johnny, a fearless 11 year old boy, his genetically engineered super talking dog Dukey, and his 13 year old super genius scientist twin sisters, Susan and Mary, who use Johnny as their guinea pig for their out-of-this-world scientific experiments. Johnny's love for video games can sometimes take him a little too far - like inside the video games.

After a short stay with an FBI agent who gives them a chance to attend school and live a normal life, the six genetically-altered, winged youths head toward Florida and Max's ultimate destiny--to save the world, whether she wants to or not.