Follows the life and loves of Sookie Stackhouse, a telepathic barmaid who lives in a small Louisiana town inhabited by both humans and vampires.

Sam returns from his aborted around-the-world boat trip to find the old gang gone. Carla and Woody are the same, but wearing uniforms more fit for a barbershop quartet. There is a tough new boss who reportedly "eats live sharks for breakfast." The new boss, Rebecca, grudgingly hires back Sam. But Rebecca is not as tough as she seems, however, getting weak in the knees at the thought or sight of her corporate boss, Evan Drake.

Season six introduces several jarring storylines. As "Billith" comes to terms with his newfound powers after emerging from a pool of blood at the end of season five, Louisiana governor Truman Burrell declares open season on vampires, replete with novel anti-vamp weapons and high-tech internment camp. Sookie and Jason steel themselves for an encounter with the killer of their parents; the mysterious and ancient Warlow.